Role of NK Cells in Cancer and Immunotherapy

Increasing knowledge of cancer immunology has led to the design therapies using immune cells directly or manipulating their activity, collectively termed immunotherapy. In field immuno-oncology, research on adaptive T development CAR-T cells. Innate such as NK can also eliminate oncogenically transformed and regulate system. Considering a live drug, numerous methods for isolation activation have been shown be clinically therapeutically relevant. processes, various cytokines antibodies present source stimulation enhance efficacy treatments. The ex vivo expansion cells, along with genetic modification CAR, antitumor activity. Recent preclinical studies an effect through extracellular vesicles (EVs) derived from Work autologous provided insights clinical applications. this review, we outline recent advances NK-cell-based immunotherapies, summarizing CAR-NK BiKEs, TriKEs treatment options against cancer. This review discusses challenges cell